Clinical Trials
-
Principal Investigator:
Uma M. Reddy, MD, MPHThis research study is being done to is to understand how CPAP for sleep apnea may affect hypertensive disorders of pregnancy and other complications of pregnancy such as gestational diabetes. The purpose of the home sleep test is to find women with sleep apnea. Sleep apnea is when you have one or more pauses in breathing or shallow breaths while you sleep. Studies have shown that women with sleep apnea have an increased risk of high blood pressure and diabetes during pregnancy. If the test shows that you have sleep apnea in the mild to moderate range you will be eligible for a research study... -
Principal Investigator:
June Y. Hou, MDThe purpose of the first part of this study, the Dose Escalation part, is to study and identify the highest tolerable safe dose of MORAb-202. Not all patients will get the same dose of the study drug. At the beginning of the study, a small group of three to six patients will receive an infusion with a low dose of the study drug. If this dose does not cause severe side effects, it will be increased for each new group of patients who participate in the study and will continue until the highest tolerable safe dose of the drug is confirmed. This dose will be selected and used as the starting dose... -
Principal Investigator:
Jason D. Wright, MDThe goal of this clinical research study is to compare the outcomes of minimally invasive surgery (the investigational surgery) to laparotomy (the current standard of care) in women with Epithelial Ovarian Cancer (EOC) who receive chemotherapy before and after surgery. Researchers want to learn if one surgery can prevent the disease from returning for longer and/or improve your quality of life after surgery. It is considered investigational to compare the outcomes of these methods when used to treat advanced EOC in women who have responded to neoadjuvant chemotherapy. -
Principal Investigator:
Jason D. Wright, MDThe main purpose of this study is to determine if two surgical procedures, the usual approach of removing the fallopian tubes and ovaries and the other approach of removing the fallopian tubes at this time with the plan to remove the ovaries at a later time, are no different for ovarian cancer risk reduction in women with BRCA1 mutations who have completed childbearing. In this study, the removal of fallopian tubes will be compared to the removal of fallopian tubes and ovaries. The study will also examine what factors go into deciding which surgery to have and symptoms after surgery caused by... -
Principal Investigator:
Carolyn L. Westhoff, MDIf you are sexually active, have normal, regular menstrual cycles, do not wish to become pregnant for at least 12 months, and are willing to try an investigational hormonal method of birth control, then you may be eligible to join the LUMINOUS Study. This study will investigate whether an investigational contraceptive patch, worn on the skin, can prevent pregnancy in women. To take part in the study, you must be willing and able to use the study patch as your only method of birth control, apply the study patch at home and undertake home pregnancy tests, complete an electronic diary with... -
Principal Investigator:
S. Zev Williams, MD, PhDResearchers at Columbia are looking at the changes that happen in the placenta when people become pregnant. Participation in this study involves a blood draw at three time points. Participants will be paid $50 at each time point. Participants who complete all three time points will receive bonus compensation. -
Principal Investigator:
S. Zev Williams, MD, PhDResearchers at Columbia are looking at the changes that happen in the placenta when people become pregnant. Participation in this study involves a blood draw at three time points. Participants will be paid $50 at each time point. Participants who complete all three time points will receive bonus compensation. -
Principal Investigator:
Jason D. Wright, MDThe purpose of this study is to find out of the combination of the drugs abemaciclib and letrozole is better or worse than usual approach for your type of cancer. The usual approach is defined as care most people get for endometrial cancer. People who are not in a study are usually treated with either surgery, radiation, hormonal therapy or with chemotherapy. Sometimes, combinations of these are used and your doctor can explain which may be best for you. These treatments can reduce symptoms and may stop the tumor from growing for several months or more. Another purpose of the study is to test... -
Principal Investigator:
June Y. Hou, MDThis research study has two parts. Participants will be enrolled in the second part of the study. The names of the study drugs are RGX-104, nivolumab, ipilimumab, docetaxel, carboplatin, and pemetrexed. The purpose of the first part of the study is to determine the highest dose of RGX-104 the body can handle. The purpose of the second part is to determine if the highest dose of RGX-104 determined in the first part might be an effective treatment option for people with advanced cancers. Both parts of the study will try to understand the safety and side effects of RGX-104. -
Principal Investigator:
June Y. Hou, MDBy doing this study, researchers hope to learn more about the efficacy (how well the drug works) and safety (the drugs side effects) of MORAb-202 (farletuzumab ecteribulin) compared to approved chemotherapy medications in patients with platinum-resistant ovarian cancer. The study will evaluate two doses of MORAb-202. MORAb-202, is made up of two parts; an antibody which targets specific proteins on the cancer cell surface and a chemotherapy drug. The antibody is absorbed into the cell and once inside the chemotherapy drug is released to attack the cancer cell. The treatment being studied,...