Vivian Shan Wei, PhD

  • Assistant Professor of Reproductive Sciences (in Obstetrics and Gynecology) at CUMC

Overview

Vivian Shan Wei is an Assistant Professor of Reproductive Sciences (in Obstetrics and Gynecology) at Columbia University Irving Medical Center. As a Havens Innovator, Dr. Wei will create and lead a successful research and development program at Columbia University Fertility Center, delivering innovative solutions to critical clinical problems.

She received a PhD from The Ohio State University and a BS from Nankai University. Dr. Wei completed her postdoctoral training in Human Genetics and Bioinformatics at Albert Einstein College of Medicine and Columbia University Irvine Medical Center. Dr. Wei leads the development and validation of innovative genetic testing and diagnostics technologies. She studies endogenous genetic instability and the causes of recurrent miscarriage and infertility using novel single-molecule sequencing, next-generation sequencing (NGS), and bioinformatics techniques. Her research has received funding from Columbia University, private foundations, and the National Institute of Health.

Academic Appointments

  • Assistant Professor of Reproductive Sciences (in Obstetrics and Gynecology) at CUMC

Credentials & Experience

Education & Training

  • PhD, The Ohio State University
  • BS, Nankai University

Research

 Innovations for the Next Generation.

Our research focuses on understanding the causes of miscarriages and recurrent pregnancy losses, aiming to deliver innovative solutions to critical clinical problems. We employ novel engineering, biochemistry, sequencing, and bioinformatics techniques to understand the essential elements for a healthy pregnancy. Teaming with Columbia University Fertility Center (CUFC), we are developing real-time monitoring assays to safeguard pregnancy health. Additionally, we have developed translational diagnostics and interventions using cutting-edge rapid sequencing techniques to enhance accessibility and improve patient reproductive care.

Research Interests

  • Bioinformatics
  • Genetic Disorders
  • Genome Instability
  • High Fidelity Next Generation Sequencing
  • Rapid Clinical Diagnostics
  • Single Molecule Sequencing

Selected Publications

  1. Wei S, Djandji A, Lattin MT, Nahum O, Hoffman N, Cujar C, Kayali R, Cinnioglu C, Wapner R, D'Alton M, Levy B, Williams Z. Rapid Nanopore Sequencing-Based Screen for Aneuploidy in Reproductive Care. N Engl J Med. 2022 Aug 18;387(7):658-660. doi: 10.1056/NEJMc2201810. PMID: 36070716.
  2. Wei S, Suryawanshi H, Djandji A, Kohl E, Morgan S, Hod EA, Whittier S, Roth K, Yeh R, Alejaldre JC, Fleck E, Ferrara S, Hercz D, Andrews D, Lee L, Hendershot KA, Goldstein J, Suh Y, Mansukhani M, Williams Z. Field-deployable, rapid diagnostic testing of saliva for SARS-CoV-2. Sci Rep. 2021 Mar 9;11(1):5448. doi: 10.1038/s41598-021-84792-8. PMID: 33750853; PMCID: PMC7943555.
  3. Wei S, Weiss ZR, Gaur P, Forman E, Williams Z. Rapid preimplantation genetic screening using a handheld, nanopore-based DNA sequencer. Fertil Steril. 2018 Oct;110(5):910-916.e2. doi: 10.1016/j.fertnstert.2018.06.014. PMID: 30316437; PMCID: PMC8756381.
  4. Wei S, Williams Z. Rapid Short-Read Sequencing and Aneuploidy Detection Using MinION Nanopore Technology. Genetics. 2016 Jan;202(1):37-44. doi: 10.1534/genetics.115.182311. Epub 2015 Oct 23. PMID: 26500254; PMCID: PMC4701100.