Matthew Hoffman, MD

Matthew K. Hoffman, MD, MPH, FACOG, is the Virgil G. Damon Professor of Obstetrics and Gynecology and Vice Chair of Research in the Department of Obstetrics and Gynecology at Columbia University Irving Medical Center. He is a board-certified obstetrician-gynecologist and clinical trialist whose work focuses on preventing preterm birth and preeclampsia and improving maternal and neonatal outcomes through clinical research and data science.

Dr. Hoffman has led major trials that have helped define contemporary obstetric care. These include ASPIRIN, a multinational randomized trial conducted through the NICHD Global Network. Published in The Lancet in 2020, the trial demonstrated that low-dose aspirin reduced preterm birth among nulliparous women in low- and middle-income countries. He also led TOPS, the NICHD Maternal-Fetal Medicine Units Network trial of cervical pessary for patients with a short cervix, published in JAMA in 2023.

His current research spans aspirin dosing and mechanisms in pregnancy, antibiotic strategies for preterm premature rupture of membranes, labor induction and shoulder dystocia, global maternal health, and machine-learning models that predict pregnancy complications. He has authored more than 180 peer-reviewed publications.

Before joining Columbia in 2026, Dr. Hoffman spent three decades at ChristianaCare in Delaware. He held the Marie E. Pinizzotto Endowed Chair of Obstetrics and Gynecology, directed obstetric and gynecologic research, and served as site principal investigator for the NICHD Maternal-Fetal Medicine Units Network from 2006 to 2025.

Dr. Hoffman received his bachelor’s degree in biochemistry, cum laude, from the University of Pennsylvania and his medical degree from the University of Florida College of Medicine. He completed his residency in obstetrics and gynecology at Pennsylvania State University College of Medicine and earned a Master of Public Health in Maternal and Child Health from the Johns Hopkins Bloomberg School of Public Health.